Since backups are the most important process regardless of what industry you are in, it pays to put a lot of thought into creating a reliable, easy-to-use, scalable, and secure backup solution.
This should be pretty obvious. Without a reliable backup solution that "just works" you can not be 100% sure that you will be able to restore any data at any time, and this clearly a bad thing. Files are lost or accidentally deleted by users and there is no excuse for not being able to restore this data.
If your backup process is not simple and painless for the end users (eg: the person or persons responsible for rotating the backup media) then sooner or later shortcuts will be taken, steps will be skipped, errors or warnings will be ignored, and you will not have the data you need when disaster strikes - and it will strike, it's just a matter of time.
How much data are you backing up today? Tomorrow? Next week, month, year? If you build a backup system to only handle your current needs, it will surely need to be replaced sooner than you'd think. You want to make sure that the backup solution you build will take care of your needs now and will continue to work into the future with minor adjustments rather than needing to be completely replaced in a year or two
The only thing more important than having good offsite backups of your data is making sure that someone else does not have access to your data. This is where encryption comes in. If your backups are written to an encrypted device (hard drive, tape drive, CDROM, etc) then you can safely transport your backup media on a regular schedule to an off-site location without the fear of your data being compromised.